Schubert J, Schmidt R, Raupach H W
Clinic of Maxillofacial Surgery, Martin-Luther-Universität Halle-Wittenberg, BRD.
J Craniomaxillofac Surg. 1990 Nov;18(8):343-7. doi: 10.1016/s1010-5182(05)80053-8.
Positive clinical results of nonspecific drug prevention in 63 pregnancies at risk, in families with occurrence of cleft lip, alveolus and palate are demonstrated. The model of cleft palate in mice, induced by dexamethasone, was used for the experimental foundation of the method. A significant decrease in the cleft palate incidence, up to 70%, was shown, when the animals were given vitamin B-complex prophylactically, simultaneously and/or therapeutically. Three main possible modes of action supported by experimental results are discussed. The results may be of interest also in respect of other malformation of multifactorial origin.
在有唇、牙槽和腭裂发生的家庭中，对63例有风险的妊娠进行非特异性药物预防取得了积极的临床结果。用地塞米松诱导的小鼠腭裂模型作为该方法的实验基础。当对动物进行预防性、同时性和/或治疗性给予复合维生素B时，腭裂发生率显著降低，高达70%。讨论了实验结果支持的三种主要可能作用模式。这些结果对于其他多因素起源的畸形也可能具有参考价值。
