Walther J U
Geburtshilfe Frauenheilkd. 1984 Sep;44(9):595-8. doi: 10.1055/s-2008-1036312.
Cheilognathopalatoschisis is among the common isolated congenital malformations. Its occurrence is more frequent than random incidence would be, with high familial incidence. Preventive attempts have been guided by the concept that nutritive factors are involved in the realisation of these inhibitory malformations. A multivitamin substitution course initiated even before conception was found to be correlated with a significant reduction of recurrence rates in several studies. The statistical and practical implications and problems are discussed. This treatment can be recommended as an individual preventive measure in case of pregnancies with risk of cheilognathopalatoschisis, but it will not be helpful in familial incidence of median cleft palate.
唇腭裂是常见的孤立性先天性畸形之一。其发生率高于随机发生率，家族发病率较高。预防措施一直以营养因素参与这些抑制性畸形的发生这一概念为指导。在几项研究中发现，甚至在受孕前就开始的多种维生素替代疗程与复发率的显著降低相关。讨论了其统计学和实际意义及问题。对于有唇腭裂风险的妊娠，这种治疗可作为一种个体预防措施推荐，但对家族性腭裂发病率无效。
