Thompson Colin, Ibie Chidinma
Robert Gordon University, School of Pharmacy and Life Sciences, Aberdeen, AB1O 1FR, UK.
Ther Deliv. 2011 Dec;2(12):1611-31. doi: 10.4155/tde.11.131.
In spite of the numerous barriers inherent in the oral delivery of therapeutically active proteins, research into the development of functional protein-delivery systems is still intense. The effectiveness of such oral protein-delivery systems depend on their ability to protect the incorporated protein from proteolytic degradation in the GI tract and enhance its intestinal absorption without significantly compromising the bioactivity of the protein. Among these delivery systems are polyelectrolyte complexes (PECs) which are composed of polyelectrolyte polymers complexed with a protein via coulombic and other interactions. This review will focus on the current status of PECs with a particular emphasis on the potential and limitations of multi- or inter-polymer PECs used to facilitate oral protein delivery.
尽管治疗活性蛋白口服给药存在诸多内在障碍，但功能性蛋白递送系统的研发仍在积极进行。此类口服蛋白递送系统的有效性取决于其保护包封蛋白免受胃肠道蛋白水解降解的能力，以及在不显著损害蛋白生物活性的情况下增强其肠道吸收的能力。这些递送系统中包括聚电解质复合物（PEC），它由聚电解质聚合物通过库仑相互作用和其他相互作用与蛋白质复合而成。本综述将聚焦于PEC的当前研究现状，特别强调用于促进口服蛋白递送的多聚合物或聚合物间PEC的潜力和局限性。
