UMR643, INSERM, Nantes 44000, France.
Curr Mol Med. 2013 Jan;13(1):80-5.
This review describes the key role of the serine-threonine kinase like protein Tribbles-1 in health as well as in diverse human pathologies. Tribbles-1 is a homolog protein of the Drosophila Tribbles. In Drosophila, the Tribbles protein is involved in the cell-cycle progression during mitosis and in mammals initial data showed TRIB1 to be involved in cell proliferation. In mammals, TRIB1 lacks a catalytic domain and thus acts as an adaptor protein by interacting with several partners. The activity of TRIB1 seems to be very specific to the environment and the cells type in which it is expressed, and a role for this molecule has been mainly described in several pathological states including various cancers such as acute myeloid leukemia and ovarian cancer. Further evidence has also linked TRIB1 to the control of plasmalipid homeostasis thus indicating the role of this molecule as a risk factor for myocardial infarction. Finally, TRIB1 is shown to be up-regulated during inflammatory events such as chronic inflammation of atherosclerotic arteries or chronic antibody-mediated rejection of transplanted organs. Here we provide a review of the current state of the scientific literature for TRIB1, highlighting its role in diverse pathologies and inflammatory states. A better understanding of the role of this protein as both a target as well as a biological marker in diseases should drive the development of new therapeutic strategies.
这篇综述描述了丝氨酸-苏氨酸激酶样蛋白 Tribbles-1 在健康以及多种人类疾病中的关键作用。Tribbles-1 是果蝇 Tribbles 的同源蛋白。在果蝇中，Tribbles 蛋白参与有丝分裂过程中的细胞周期进程，而在哺乳动物中，最初的数据表明 TRIB1 参与细胞增殖。在哺乳动物中，TRIB1 缺乏催化结构域，因此作为一种衔接蛋白通过与多个伴侣相互作用。TRIB1 的活性似乎对其表达的环境和细胞类型非常特异，该分子的作用主要在几种病理状态中描述，包括各种癌症，如急性髓系白血病和卵巢癌。进一步的证据还将 TRIB1 与血浆脂质稳态的控制联系起来，从而表明该分子是心肌梗死的一个风险因素。最后，TRIB1 在动脉粥样硬化的慢性炎症或移植器官的慢性抗体介导的排斥等炎症事件中被上调。在这里，我们对 TRIB1 的科学文献进行了综述，突出了它在多种病理和炎症状态中的作用。更好地理解该蛋白作为疾病的治疗靶点和生物标志物的作用，应该会推动新的治疗策略的发展。
