Department of Diagnosis and Surgery, Division of Periodontology, UNESP- Univ, Estadual Paulista, School of Dentistry, Rua Humaitá, 1680, Araraquara, SP, 14801-903, Brazil.
Head Face Med. 2012 Jul 26;8:20. doi: 10.1186/1746-160X-8-20.
Atraumatic teeth extractions protocols are highly encouraged in patients taking bisphosphonates (Bps) to reduce surgical trauma and, consequently, the risk of jaws osteonecrosis development. In this way, this paper aims to report the findings of increased surgical difficulty during simple exodontias in animals treated with bisphosphonates.
Sixty male Holtzman rats were randomly distributed into three groups of 20 animals and received daily subcutaneous administration of 1 mg/kg (AL1) or 3 mg/kg (AL3) of alendronate or saline solution (CTL). After 60 days of drug therapy all animals were submitted to first lower molars extractions under general anesthesia. Operatory surgical time and the frequency of teeth fractures were measured as principal outcomes and indicators of surgical difficulty degree.
Animals treated with alendronate (AL1 and AL3) were associated to higher operatory times and increased frequency of teeth fractures compared to match controls.
The bisphosphonate therapy may be associated with an increased surgical difficulty and trauma following simple exodontias protocols, which is considered a critical issue when it comes to osteonecrosis development.
为了降低手术创伤，进而降低颌骨坏死发展风险，接受双膦酸盐（Bps）治疗的患者强烈推荐采用微创拔牙术。因此，本文旨在报告在接受双膦酸盐治疗的动物中，微创拔牙术时手术难度增加的发现。
60 只雄性霍尔茨曼大鼠随机分为三组，每组 20 只，每天接受 1mg/kg（AL1）或 3mg/kg（AL3）的阿仑膦酸钠或生理盐水（CTL）的皮下注射。药物治疗 60 天后，所有动物均在全身麻醉下进行下颌第一磨牙拔除术。主要观察指标为手术操作时间和牙齿骨折的频率，以评估手术难度。
与匹配对照组相比，接受阿仑膦酸钠（AL1 和 AL3）治疗的动物手术时间更长，牙齿骨折的频率更高。
双膦酸盐治疗可能与微创拔牙术后手术难度增加和创伤增加相关，这在颌骨坏死发展方面是一个关键问题。
