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儿科领域的人体生物学:测量儿童期的骨矿物质积累

Human biology at the interface of paediatrics: measuring bone mineral accretion during childhood.

作者信息

Zemel Babette S

机构信息

Division of Gastroenterology, Hepatology and Nutrition, The Children's Hospital of Philadelphia, The Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, room 1560, Philadelphia, PA 19104-4399, USA.

出版信息

Ann Hum Biol. 2012 Sep;39(5):402-11. doi: 10.3109/03014460.2012.704071. Epub 2012 Jul 27.

Abstract

BACKGROUND

Professor Tanner established a paradigm for the study of growth and development that demands precise growth measurements, description of normal variability through development to adulthood, consideration of the effects of tempo and the study of factors that influence growth outcomes. The relatively new field of paediatric bone health assessment fits this paradigm and reflects the collaboration of human biologists and paediatricians in understanding the growth of the human skeleton.

REVIEW

This review describes the reasons for clinical assessment of bone density in children, the technological developments in bone health assessment in children, the development of reference curves and the effects of growth, body composition, pubertal timing, genetics and lifestyle on bone health outcomes.

摘要

背景

Tanner教授建立了一个用于生长发育研究的范式,该范式要求进行精确的生长测量,描述从发育到成年期的正常变异性,考虑生长速度的影响以及对影响生长结果的因素进行研究。儿科骨健康评估这一相对较新的领域符合该范式,体现了人类生物学家和儿科医生在理解人类骨骼生长方面的合作。

综述

本综述描述了儿童骨密度临床评估的原因、儿童骨健康评估的技术发展、参考曲线的制定以及生长、身体成分、青春期时间、遗传学和生活方式对骨健康结果的影响。

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