Davies J H, Evans B A J, Gregory J W
Department of Child Health, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Arch Dis Child. 2005 Apr;90(4):373-8. doi: 10.1136/adc.2004.053553.
Although 80% of the variance in bone mass is determined genetically, there are many other factors which influence the accumulation of bone in early life and affect future risks of osteoporosis. This review considers the genetic, fetal, and environmental influences on bone mass acquisition in healthy children, and highlights important areas where paediatricians may have a role by counselling children and their families to adopt a healthy lifestyle which promotes bone health.
尽管骨量80%的差异由基因决定,但还有许多其他因素会影响生命早期的骨量积累,并影响未来患骨质疏松症的风险。本文综述了健康儿童骨量获取过程中的遗传、胎儿期及环境影响因素,并着重指出了重要领域,儿科医生可通过向儿童及其家庭提供咨询,促使他们采取促进骨骼健康的健康生活方式,在这些领域发挥作用。