Byrd K E, Stein S T
Department of Basic Sciences, University of Southern California, School of Dentistry, Los Angeles 90089-0641.
J Oral Rehabil. 1990 Nov;17(6):529-40. doi: 10.1111/j.1365-2842.1990.tb01424.x.
Stereotaxic surgery was performed on the trigeminal motor nuclei (TMNu) of 47 actively growing rats in order to test the effects of neuromuscular alterations on TMJ disc morphology. Lesioned animals received a small electrolytic lesion to their left-side TMNu, while shams had their TMNu stimulated without an actual lesion being produced. Both lesioned and sham-lesioned animals demonstrated significant (P less than 0.05; P less than 0.01) morphological alterations of their discs 28, 56, and 84 days postoperatively. Data indicated that (i) TMNu lesions do indeed affect disc morphology, and (ii) even subtle damage to trigeminal motoneurones can influence TMJ disc morphology. It is therefore suggested that at least some TMJ disease processes have a neuromuscular basis.
为了测试神经肌肉改变对颞下颌关节盘形态的影响，对47只生长活跃的大鼠的三叉神经运动核（TMNu）进行了立体定向手术。损伤组动物的左侧TMNu接受了微小的电解损伤，而假手术组则刺激其TMNu但未产生实际损伤。损伤组和假损伤组动物在术后28天、56天和84天均表现出关节盘明显的（P<0.05；P<0.01）形态学改变。数据表明：（i）TMNu损伤确实会影响关节盘形态，（ii）即使三叉神经运动神经元受到轻微损伤也会影响颞下颌关节盘形态。因此提示至少某些颞下颌关节疾病过程具有神经肌肉基础。
