Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/East, Gothenburg, Sweden.
Am J Obstet Gynecol. 2012 Sep;207(3):212.e1-7. doi: 10.1016/j.ajog.2012.06.002. Epub 2012 Jun 11.
The purpose of this study was to determine the influence of maternal prepregnancy body mass index on preterm delivery (PTD), controlling for health and lifestyle variables.
Prospective data were from 83,544 pregnancies in the Norwegian Mother and Child Cohort Study. PTD was divided into early PTD (22 + 0 to 31 + 6 weeks' gestation) and late PTD (32 + 0 to 36 + 6 weeks' gestation).
The overall prevalence of PTD was 5.1%. Increased body mass index was associated with an increased risk of PTD; adjusted odds ratio (aOR) ranged from 1.11 (95% confidence interval [CI], 1.03-1.20) for preobesity to 2.00 (95% CI, 1.48-2.71) for grade-III obesity in the group that included all PTD subgroups. Grade-III obese women had an increased risk of both early and late PTD: aOR, 3.24 (95% CI, 1.71-6.14) and 1.81 (95% CI, 1.29-2.54), respectively.
Prepregnancy maternal overweight increases the risk of both early and late PTD.
本研究旨在确定母亲孕前体重指数对早产（PTD）的影响，同时控制健康和生活方式变量。
前瞻性数据来自挪威母婴队列研究中的 83544 例妊娠。早产分为早期早产（22+0 至 31+6 周妊娠）和晚期早产（32+0 至 36+6 周妊娠）。
总体早产率为 5.1%。体重指数增加与早产风险增加相关；调整后的优势比（aOR）范围从肥胖前期的 1.11（95%置信区间 [CI]，1.03-1.20）到肥胖 3 级的 2.00（95%CI，1.48-2.71），包括所有早产亚组。肥胖 3 级的妇女有发生早期和晚期早产的风险增加：aOR 分别为 3.24（95%CI，1.71-6.14）和 1.81（95%CI，1.29-2.54）。
孕前母亲超重会增加早产的风险，无论是早期还是晚期。
