Smith Anthony J, Smith James G, Shelton Richard M, Cooper Paul R
School of Dentistry, University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK.
Dent Clin North Am. 2012 Jul;56(3):589-601. doi: 10.1016/j.cden.2012.05.011. Epub 2012 Jun 22.
Biological solutions for the repair and regeneration of the dental tissues offer significant potential for improved clinical treatment outcomes. Translation of dental tissue-engineering approaches to the clinic will make considerable contributions to these outcomes in the future, but exploiting the natural regenerative potential of dentin-pulp to enhance wound-healing responses offers solutions for maintaining pulp vitality now. Strategies to harness the natural regenerative potential of the pulp must be based on a sound biological understanding of the cellular and molecular events taking place, and require careful consideration of the interplay of infection, inflammation, and regeneration.
用于牙齿组织修复和再生的生物解决方案为改善临床治疗效果提供了巨大潜力。将牙齿组织工程方法转化应用于临床,未来将对这些治疗效果做出重大贡献,但利用牙本质-牙髓的天然再生潜力来增强伤口愈合反应,可为当下维持牙髓活力提供解决方案。利用牙髓天然再生潜力的策略必须基于对所发生的细胞和分子事件的深入生物学理解,并且需要仔细考虑感染、炎症和再生之间的相互作用。