Simon S R J, Berdal A, Cooper P R, Lumley P J, Tomson P L, Smith A J
INSERM, UMR S, Centre de recherche des Cordeliers, Paris, France.
Adv Dent Res. 2011 Jul;23(3):340-5. doi: 10.1177/0022034511405327.
Dentistry is entering an exciting era in which many of the advances in biotechnology offer opportunities for exploitation in novel and more effective therapies. Pulp healing is complex and dependent on the extent of injury, among many other factors. Many of the molecular and cellular processes involved in these healing events recapitulate developmental processes. The regulation of odontoblast activity is clearly central to pulp healing, and an understanding of the mechanisms involved in these processes is necessary to enable laboratory studies to be translated to clinic application. Transcriptome analysis has identified changes in many odontoblast genes during the life-cycle of this cell and its responses to injurious challenge. The p38 MAPKinase pathway appears to be central to the transcriptional control of odontoblasts and may provide a key target for therapeutic intervention. The many recent advances in knowledge of pulpal stem cells and molecular signaling molecules within the tooth, now provide exciting opportunities for clinical translation to novel therapies. Such translation will require the partnership of researchers and skilled clinicians who can effectively apply advances in knowledge to appropriate clinical cases and develop novel therapies which can be realistically introduced into the clinic.
牙科正进入一个令人兴奋的时代，生物技术的许多进展为开发新颖且更有效的治疗方法提供了机会。牙髓愈合过程复杂，且在许多其他因素中，还取决于损伤的程度。这些愈合事件中涉及的许多分子和细胞过程重现了发育过程。成牙本质细胞活性的调节显然是牙髓愈合的核心，了解这些过程中涉及的机制对于使实验室研究转化为临床应用是必要的。转录组分析已经确定了在成牙本质细胞的生命周期及其对损伤性挑战的反应过程中，许多成牙本质细胞基因的变化。p38丝裂原活化蛋白激酶途径似乎是成牙本质细胞转录控制的核心，可能为治疗干预提供关键靶点。目前，牙髓干细胞和牙齿内分子信号分子的知识有了许多最新进展，为临床转化为新疗法提供了令人兴奋的机会。这种转化将需要研究人员和技术熟练的临床医生的合作，他们能够将知识进展有效地应用于适当的临床病例，并开发出能够切实引入临床的新疗法。
