Division of Vascular Surgery, Department of Surgery, The University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong.
Eur J Vasc Endovasc Surg. 2012 Oct;44(4):399-405. doi: 10.1016/j.ejvs.2012.06.004. Epub 2012 Jul 25.
The aim of this study is to present novel ex-vivo models in the study of complex haemodynamical changes in Stanford type B aortic dissection (TBAD).
Fifteen fresh porcine aortas were harvested and preserved with 4 °C saline. Ex-vivo models were developed to simulate TBAD in three different situations: model A with patent false lumen, model B with distal re-entry only and model C with proximal primary entry only. These models were connected to standardised pulsatile pumps and the pressure waveforms were monitored and compared. The aortas were scanned with ultrasonography and subjected to post-experiment autopsy.
The three different models were successfully created (n = 13). Pulsatile flow testing was successful and the shapes of the pressure waveforms were similar to those taken from human aorta. Post-testing gross examination confirmed the success of modelling.
Porcine aortas may prove to be useful ex-vivo models in the study of aortic dissection haemodynamics. These models are reproducible and may be used in the study of complex haemodynamic forces during the development and propagation of TBAD. Our three porcine models give a potential possibility in helping clinicians isolate and analyse complex haemodynamical factors in the development, propagation and prognosis of TBAD.
本研究旨在介绍新型的斯坦福 B 型主动脉夹层（TBAD）复杂血流动力学变化的体外模型。
采集并保存在 4°C 盐水中的 15 个新鲜猪主动脉。体外模型分别在三种不同情况下模拟 TBAD：模型 A 为假腔通畅，模型 B 为仅远端再入口，模型 C 为仅近端原发入口。这些模型与标准化脉动泵相连，监测并比较压力波形。使用超声心动图扫描主动脉，并进行实验后解剖。
成功建立了三种不同的模型（n = 13）。脉动流测试成功，压力波形的形状与从人体主动脉获得的形状相似。测试后大体检查证实了建模的成功。
猪主动脉可能是研究主动脉夹层血流动力学的有用的体外模型。这些模型具有可重复性，可用于研究 TBAD 发展和传播过程中复杂的血流动力。我们的三种猪模型为帮助临床医生在 TBAD 的发展、传播和预后中分离和分析复杂的血流动力学因素提供了潜在的可能性。
