Renal Division, Department of Medicine, Peking University First Hospital, Beijing, Peoples Republic of China.
Am J Kidney Dis. 2012 Dec;60(6):1044-8. doi: 10.1053/j.ajkd.2012.05.023. Epub 2012 Jul 25.
Lymphoblastic lymphoma is an uncommon subtype of lymphoid neoplasm in adults. Acute kidney injury at initial presentation due to lymphoblastic lymphoma infiltration of the kidneys has rarely been described. We report a 19-year-old woman who presented with acute kidney injury due to massive lymphomatous infiltration of the kidneys. The diagnosis of B-cell lymphoblastic lymphoma was established by immunohistochemical study of the biopsied kidney. The patient had an excellent response to the VDCLP protocol (vincristine, daunomycin, cyclophosphamide, asparaginase, and dexamethasone) with sustained remission. We recommend that lymphomatous infiltration be considered in patients presenting with unexplained acute kidney injury and enlarged kidneys.
成人淋巴母细胞淋巴瘤是一种罕见的淋巴肿瘤亚型。由于淋巴母细胞淋巴瘤浸润肾脏导致的首发急性肾损伤很少有报道。我们报告了一例 19 岁女性，因肾脏大量淋巴瘤浸润导致急性肾损伤。通过对活检肾脏进行免疫组化研究，诊断为 B 细胞淋巴母细胞淋巴瘤。该患者对 VDCLP 方案（长春新碱、柔红霉素、环磷酰胺、门冬酰胺酶和地塞米松）反应良好，持续缓解。我们建议对于不明原因的急性肾损伤和肾脏肿大的患者，应考虑淋巴瘤浸润的可能性。
