Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario K1H 8L1, Canada.
Trends Immunol. 2012 Nov;33(11):535-45. doi: 10.1016/j.it.2012.06.004. Epub 2012 Jul 24.
The inhibitor of apoptosis (IAP) genes are critical regulators of multiple pathways that control cell death, proliferation, and differentiation. Several members of the IAP family regulate innate and adaptive immunity through modulation of signal transduction pathways, cytokine production, and cell survival. The regulation of immunity by the IAPs is primarily mediated through the ubiquitin ligase function of cellular IAP (cIAP)1, cIAP2, and X-linked IAP (XIAP), the targets of which impact nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signalling pathways. In addition, neuronal apoptosis inhibitory protein (NAIP), cIAP1, and cIAP2 modulate innate immune responses through control of the inflammasome complex. This review examines the role of mammalian IAPs in regulating immunity and describes the implications of a new class of pan-IAP antagonists for the treatment of immune disorders.
凋亡抑制因子 (IAP) 基因是调控细胞死亡、增殖和分化的多种途径的关键调节剂。IAP 家族的几个成员通过调节信号转导途径、细胞因子产生和细胞存活来调节先天和适应性免疫。IAP 对免疫的调节主要是通过细胞凋亡抑制蛋白 (cIAP)1、cIAP2 和 X 连锁凋亡抑制蛋白 (XIAP) 的泛素连接酶功能介导的，这些蛋白的靶标影响核因子 (NF)-κB 和丝裂原活化蛋白激酶 (MAPK) 信号通路。此外，神经元凋亡抑制蛋白 (NAIP)、cIAP1 和 cIAP2 通过控制炎症小体复合物来调节先天免疫反应。这篇综述探讨了哺乳动物 IAP 在调节免疫中的作用，并描述了一类新型的泛 IAP 拮抗剂在治疗免疫紊乱中的意义。
