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静脉腔内激光治疗伴外部空气冷却的功能不全大隐静脉的数值模拟。

Numerical simulation of endovenous laser treatment of the incompetent great saphenous vein with external air cooling.

机构信息

INSERM-U703, Université Lille Nord de France, Lille University Hospital, 152, rue du Dr. Yersin, Loos, 59120, Lille, France.

出版信息

Lasers Med Sci. 2013 May;28(3):833-44. doi: 10.1007/s10103-012-1141-0. Epub 2012 Jul 27.

Abstract

Endovenous laser treatment (ELT) has been proposed as an alternative in the treatment of reflux of the great saphenous vein. Before the procedure, peri-saphenous subcutaneous tumescent saline solution infiltration is usually performed. However, diffusion of this tumescent fluid is rapidly observed and can potentially reduce the efficacy as a heat sink. External skin cooling with cold air was proposed as an alternative solution. The objective of this study is to compare endovenous laser treatment without and with air cooling by realistic numerical simulations. An optical-thermal damage model was formulated and implemented using finite element modeling. The general model simulated light distribution using the diffusion approximation of the transport theory, temperature rise using the bioheat equation, and laser-induced injury using the Arrhenius damage model. Parameters, used in clinical procedures, were considered: power, 15 W; pulse duration, 1 s; fiber pull back, 3-mm increments every second; cold air applied in continuous mode during ELT; and no tumescent anesthesia. Simulations were performed for vein locations at 5, 10, and 15 mm in depth, with and without air cooling. For a vein located at 15 mm in depth, no significant difference was observed with and without cooling. For a vein located at 10 mm in depth, surface temperature increase up to 45 °C is observed without cooling. For a vein located at 5 mm, without cooling, temperature increase leads to irreversible damage of dermis and epidermis. Conversely, with air cooling, surface temperature reaches a maximum of 38 °C in accordance with recordings performed on patients. ELT of the incompetent great saphenous vein with external air cooling system is a promising therapy technique. Use of cold air on the skin continuously flowing in the area of laser shot decreased significantly the heat extent and the thermal damage in the perivenous tissues and the skin.

摘要

静脉内激光治疗(ELT)已被提议作为治疗大隐静脉反流的替代方法。在进行该手术之前,通常会在大隐静脉周围皮下注射肿胀盐水溶液。然而,这种肿胀液会迅速扩散,可能会降低作为热汇的效果。因此,提出了使用冷空气对外皮进行冷却作为替代方法。本研究的目的是通过现实的数值模拟比较无空气冷却和有空气冷却的静脉内激光治疗。采用有限元建模方法构建并实现了光热损伤模型。该通用模型使用传输理论的扩散近似来模拟光分布,使用生物热方程来模拟温度升高,使用阿累尼乌斯损伤模型来模拟激光诱导损伤。考虑了临床程序中使用的参数:功率为 15 W,脉冲持续时间为 1 s,光纤以 3 mm 的增量每秒后退一次,在 ELT 过程中连续应用冷空气,并且没有肿胀麻醉。模拟了位于 5、10 和 15 mm 深度处的静脉位置,有无空气冷却两种情况。对于位于 15 mm 深度的静脉,有和没有冷却时没有明显差异。对于位于 10 mm 深度的静脉,没有冷却时,表面温度会升高到 45°C。对于位于 5 mm 深度的静脉,如果没有冷却,温度升高会导致真皮和表皮不可逆损伤。相反,使用空气冷却时,表面温度最高可达 38°C,这与在患者身上进行的记录相符。使用外部空气冷却系统对大隐静脉的不可控反流进行静脉内激光治疗是一种很有前途的治疗技术。连续地将冷空气应用于激光照射区域的皮肤,可以显著减少周围组织和皮肤的热量和热损伤程度。

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