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比较用于静脉内激光消融的980 - 1470纳米激光波长时局部冷却对穿孔率的影响:双盲体外实验研究

Local cooling effect on perforation rates comparing the 980-1470 nm laser wavelengths used with endovenous laser ablation: double blind in vitro experimental study.

作者信息

Tarhan I A, Dumantepe M, Yurdakul I, Kehlibar T, Ozler A

机构信息

Department of Cardiovascular Surgery.

出版信息

Phlebology. 2014 Mar;29(2):120-5. doi: 10.1258/phleb.2012.012021. Epub 2013 May 6.

Abstract

OBJECTIVE

Endovenous laser treatment (EVLA) is fast gaining acceptance as an alternative to open surgery for the treatment of saphenous vein incompetence. The method of action of these techniques is based on heat, making tumescence anaesthesia necessity. Heat-induced complications may occur with inadequate application of tumescent anaesthesia. Our hypothesis was, local cooling effect of tumescent anaesthesia on tunica adventitia might be kept undamaged from disruption due to the thermal injury.

METHODS

We experimented with two popular laser wavelengths (980 and 1470 nm) and with two different thermal media (+4 and +24) in vitro for perforation. Twenty different 12 cm length vein pieces were numbered randomly to set up four groups of the experiment. Endovenous laser procedures were applied in same manner in a unique design test tube with same energy density per pieces on same duration (10 W/second) (linear endovenous energy density 60 J/cm). Procedure video was recorded for macroscopic perforations. All postprocedure vein segments were examined microscopically.

RESULTS

Activities of both wavelengths were much better in cold medium (P < 0.05). Cold tumescent anaesthesia reduces the bleeding complication rate. But the performance of 1470 nm laser was better than that of 980 nm in cold environment (P = 0.0136).

CONCLUSIONS

It can be commented that reducing the ambient temperature is more beneficial than modifying the laser wavelength on perforation rates. Therefore we suppose tumescent anaesthesia temperature is effective on perforation independently from the wavelengths or type of the laser fibre.

摘要

目的

静脉内激光治疗(EVLA)作为治疗大隐静脉功能不全的开放手术替代方法正迅速得到认可。这些技术的作用方法基于热,这使得肿胀麻醉成为必要。肿胀麻醉应用不充分可能会发生热诱导并发症。我们的假设是,肿胀麻醉对血管外膜的局部冷却作用可能不会因热损伤而受到破坏。

方法

我们在体外使用两种常用的激光波长(980和1470纳米)以及两种不同的热介质(+4和+24)进行穿孔实验。将20个不同的12厘米长的静脉段随机编号,以建立四组实验。在一个独特设计的试管中,以相同的方式对每段静脉进行静脉内激光操作,每段的能量密度相同,持续时间相同(10瓦/秒)(线性静脉内能量密度60焦/厘米)。记录操作视频以观察宏观穿孔情况。对所有术后静脉段进行显微镜检查。

结果

在冷介质中,两种波长的活性都要好得多(P < 0.05)。冷肿胀麻醉可降低出血并发症发生率。但在冷环境中,1470纳米激光的性能优于980纳米激光(P = 0.0136)。

结论

可以说,降低环境温度对穿孔率的益处大于改变激光波长。因此我们认为,肿胀麻醉温度对穿孔有效,与激光纤维的波长或类型无关。

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