Ranjithkumar Muthusamy, Malik Tauseef Ahmed, Saxena Anju, Dan Ananya, Sakthivel Pillanatham Civalingam, Dey Sahadeb
Division of Medicine, Indian Veterinary Research Institute, Izatnagar, 243122, India.
Trop Anim Health Prod. 2013 Feb;45(2):417-21. doi: 10.1007/s11250-012-0232-z. Epub 2012 Jul 27.
Trypanosomiasis caused by Trypanosoma evansi commonly produces wasting disease with signs of emaciation and cachexia mainly at the end stage. The present study was conducted to explore the possible hyperlipaemia or hyperlipidaemia and its association with cachexia-anorexia in equine trypanosomiasis. Out of the fifteen confirmed animals, none of the plasma sample was opaque. There was a significant increase in plasma triglyceride, total cholesterol and blood urea nitrogen and a highly significant increase in low-density lipoprotein (LDL) levels. A mild increase in high-density lipoprotein (HDL) and very low-density lipoprotein levels were observed, while the relative percentage of HDL and LDL was altered with high significance. A moderate increase in triglyceride and highly significant increase in LDL might be the reasons for retention of appetite and lipolysis. Possible protein breakdown and presence of lipolysis might be the reasons for cachexia in equine trypanosomiasis.
由伊氏锥虫引起的锥虫病通常会引发消瘦病，主要在末期出现消瘦和恶病质症状。本研究旨在探讨马锥虫病中可能存在的高脂血症及其与恶病质 - 厌食症的关联。在15只确诊动物中，没有一份血浆样本是浑浊的。血浆甘油三酯、总胆固醇和血尿素氮显著升高，低密度脂蛋白（LDL）水平极显著升高。观察到高密度脂蛋白（HDL）和极低密度脂蛋白水平有轻度升高，而HDL和LDL的相对百分比有极显著改变。甘油三酯适度升高和LDL极显著升高可能是食欲保留和脂肪分解的原因。可能的蛋白质分解和脂肪分解的存在可能是马锥虫病中恶病质的原因。
