Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.
Autophagy. 2012 Aug;8(8):1279-80. doi: 10.4161/auto.20828. Epub 2012 Jul 27.
In recent years, tremendous progress has been made toward unveiling the mechanism of autophagy and its exploitation by many different cancer types. This year the American Association for the Advancement of Science held a one day Symposium on Autophagy: An Emerging Therapeutic Target in Human Disease in Vancouver, British Columbia and brought together experts in cell biology, drug discovery, and clinical translation to share their research findings and prospects. Currently, autophagy is being investigated on several fronts, from modulation of gene expression to in vivo studies, and more recently clinical trials in cancer. Key topics of discussion were determining which stage of autophagy would be the ideal target for inhibition to produce the highest impact, and which cancers or cancer subtypes would be the most sensitive to autophagy inhibitors; the answers to these questions may be a turning point in cancer therapy research.
近年来，人们在揭示自噬机制及其在许多不同癌症类型中的作用方面取得了巨大进展。今年，美国科学促进会在不列颠哥伦比亚省温哥华举办了为期一天的自噬研讨会：人类疾病中的新兴治疗靶点，并汇集了细胞生物学、药物发现和临床转化方面的专家，分享他们的研究成果和前景。目前，自噬正在从基因表达调控到体内研究等多个方面进行研究，最近还在癌症的临床试验中进行研究。讨论的重点是确定自噬的哪个阶段将是抑制的理想目标，以产生最大的影响，以及哪些癌症或癌症亚型对自噬抑制剂最敏感；这些问题的答案可能是癌症治疗研究的一个转折点。
