Genome Sciences Centre; BC Cancer Agency; Vancouver, BC CA; Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, BC CA.
Autophagy. 2013 Dec;9(12):2180-2. doi: 10.4161/auto.26378. Epub 2013 Sep 30.
Multidisciplinary approaches are increasingly being used to elucidate the role of autophagy in health and disease and to harness it for therapeutic purposes. The broad range of topics included in the program of the Vancouver Autophagy Symposium (VAS) 2013 illustrated this multidisciplinarity: structural biology of Atg proteins, mechanisms of selective autophagy, in silico drug design targeting ATG proteins, strategies for drug screening, autophagy-metabolism interplay, and therapeutic approaches to modulate autophagy. VAS 2013 took place at the British Columbia Cancer Research Centre, and was hosted by the CIHR Team in Investigating Autophagy Proteins as Molecular Targets for Cancer Treatment. The program was designed as a day of research exchanges, featuring two invited keynote speakers, internationally recognized for their groundbreaking contributions in autophagy, Dr Ana Maria Cuervo (Albert Einstein College of Medicine, Bronx, NY) and Dr Jayanta Debnath (University of California, San Francisco). By bringing together international and local experts in cell biology, drug discovery, and clinical translation, the symposium facilitated rich interdisciplinary discussions focused on multiple forms of autophagy and their regulation and modulation in the context of cancer.
多学科方法越来越多地被用于阐明自噬在健康和疾病中的作用，并利用它来达到治疗目的。2013 年温哥华自噬研讨会（VAS）的项目广泛涵盖了自噬的多个方面：自噬蛋白的结构生物学、选择性自噬的机制、靶向 ATG 蛋白的计算机药物设计、药物筛选策略、自噬-代谢相互作用以及调节自噬的治疗方法。VAS 2013 在不列颠哥伦比亚癌症研究中心举行，由加拿大卫生研究院（CIHR）团队主办，该团队致力于研究自噬蛋白作为癌症治疗的分子靶点。该计划旨在进行一天的研究交流，邀请了两位国际知名的自噬领域的开创性贡献者担任主题演讲嘉宾，他们是 Ana Maria Cuervo 博士（纽约州阿尔伯特·爱因斯坦医学院）和 Jayanta Debnath 博士（加利福尼亚大学旧金山分校）。通过汇集细胞生物学、药物发现和临床转化方面的国际和本地专家，研讨会促进了富有成效的跨学科讨论，重点关注多种形式的自噬及其在癌症背景下的调控和调节。
