School of Medicine, University of Southampton, UK.
J Nutr Health Aging. 2012 Jul;16(7):609-15. doi: 10.1007/s12603-012-0053-9.
Lower muscle strength is associated with a range of adverse health outcomes in later life. The variation in muscle strength between individuals is only partly accounted for by factors in adult life such as body size and physical activity. The aim of this review was to assess the strength of the association between intrauterine development (indicated by birth weight) and subsequent muscle strength.
Systematic review and meta-analysis of studies that assessed the association between birth weight and subsequent muscle strength.
Nineteen studies met inclusion criteria with 17 studies showing that higher birth weight was associated with greater muscle strength. Grip strength was used as a single measure of muscle strength in 15 studies. Meta-analysis (13 studies, 20 481 participants, mean ages 9.3 to 67.5) showed a 0.86 kg (95% CI 0.58, 1.15) increase in muscle strength per additional kilogram of birth weight, after adjustment for age, gender and height at the time of strength measurement.
This review has found consistent evidence of a positive association between birth weight and muscle strength which is maintained across the lifecourse. Future work will be needed to elucidate the biological mechanisms underlying this association, but it suggests the potential benefit of an early intervention to help people maintain muscle strength in later life.
肌肉力量较弱与晚年多种健康不良结局相关。个体间肌肉力量的差异仅部分由成年后因素决定，如体型和身体活动。本综述的目的是评估宫内发育（以出生体重为指标）与随后肌肉力量之间的关联强度。
评估出生体重与随后肌肉力量之间关联的研究进行系统性回顾和荟萃分析。
19 项研究符合纳入标准，其中 17 项研究表明出生体重越高，肌肉力量越大。15 项研究中仅使用握力作为肌肉力量的单一测量指标。荟萃分析（13 项研究，20481 名参与者，平均年龄 9.3 至 67.5 岁）表明，在调整力量测量时的年龄、性别和身高后，出生体重每增加 1 公斤，肌肉力量增加 0.86 公斤（95%CI0.58，1.15）。
本综述发现出生体重与肌肉力量之间存在积极关联的一致证据，这种关联在整个生命周期中都得到维持。未来需要进一步阐明这种关联的生物学机制，但这表明早期干预有可能帮助人们在晚年保持肌肉力量。
