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The secreted G protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement.人呼吸道合胞病毒分泌的 G 蛋白拮抗涉及巨噬细胞和补体的抗体介导的复制限制。
J Virol. 2012 Oct;86(19):10880-4. doi: 10.1128/JVI.01162-12. Epub 2012 Jul 25.
2
The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes.呼吸道合胞病毒G糖蛋白的分泌形式通过充当抗原诱饵以及对携带Fc受体的白细胞产生影响，帮助病毒逃避抗体介导的复制限制。
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3
Effects of Alterations to the CX3C Motif and Secreted Form of Human Respiratory Syncytial Virus (RSV) G Protein on Immune Responses to a Parainfluenza Virus Vector Expressing the RSV G Protein.人呼吸道合胞病毒（RSV） G 蛋白 CX3C 基序和分泌形式改变对表达 RSV G 蛋白的副流感病毒载体免疫反应的影响。
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4
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A Single-Dose Recombinant Parainfluenza Virus 5-Vectored Vaccine Expressing Respiratory Syncytial Virus (RSV) F or G Protein Protected Cotton Rats and African Green Monkeys from RSV Challenge.一种表达呼吸道合胞病毒（RSV）F或G蛋白的单剂量重组副流感病毒5载体疫苗可保护棉鼠和非洲绿猴免受RSV攻击。
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Characterization of the role of N-glycosylation sites in the respiratory syncytial virus fusion protein in virus replication, syncytium formation and antigenicity.鉴定 N-糖基化位点在呼吸道合胞病毒融合蛋白在病毒复制、合胞体形成和抗原性中的作用。
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Evaluation of the respiratory syncytial virus G-directed neutralizing antibody response in the human airway epithelial cell model.评价呼吸道合胞病毒 G 指导的中和抗体反应在人呼吸道上皮细胞模型中的作用。
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Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice.呼吸道合胞病毒G蛋白和/或SH蛋白可改变BALB/c小鼠肺部感染时的Th1细胞因子、自然杀伤细胞及中性粒细胞反应。
J Virol. 1999 Sep;73(9):7099-107. doi: 10.1128/JVI.73.9.7099-7107.1999.
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Immunogenicity and inflammatory properties of respiratory syncytial virus attachment G protein in cotton rats.呼吸道合胞病毒附着 G 蛋白在棉鼠中的免疫原性和炎症特性。
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Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivo.呼吸道合胞病毒G糖蛋白及其分泌型和膜结合型对病毒体内外复制的作用
Virology. 2001 Oct 25;289(2):283-96. doi: 10.1006/viro.2001.1138.

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1
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Methods Mol Biol. 2025;2948:59-71. doi: 10.1007/978-1-0716-4666-3_4.
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Pneumonia (Nathan). 2025 Jun 25;17(1):15. doi: 10.1186/s41479-025-00165-z.
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Layer-by-Layer Microparticle Vaccines Containing a S177Q Point Mutation in the Central Conserved Domain of the RSV G Protein Improves Immunogenicity.在呼吸道合胞病毒G蛋白中央保守结构域含有S177Q点突变的逐层微颗粒疫苗可提高免疫原性。
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6
Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system.针对埃博拉病毒糖蛋白糖帽的抗体是补体系统的有效诱导剂。
Commun Biol. 2024 Jul 17;7(1):871. doi: 10.1038/s42003-024-06556-0.
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Emerging role of complement in COVID-19 and other respiratory virus diseases.补体系统在 COVID-19 和其他呼吸道病毒疾病中的新作用。
Cell Mol Life Sci. 2024 Feb 18;81(1):94. doi: 10.1007/s00018-024-05157-8.
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Fc-mediated functions of nirsevimab complement direct respiratory syncytial virus neutralization but are not required for optimal prophylactic protection.Fc 介导的 nirsevimab 功能补充了直接呼吸道合胞病毒中和作用，但不是最佳预防保护所必需的。
Front Immunol. 2023 Oct 11;14:1283120. doi: 10.3389/fimmu.2023.1283120. eCollection 2023.
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Immune Prophylaxis Targeting the Respiratory Syncytial Virus (RSV) G Protein.针对呼吸道合胞病毒（RSV）G 蛋白的免疫预防。
Viruses. 2023 Apr 27;15(5):1067. doi: 10.3390/v15051067.
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Scratching the Surface Takes a Toll: Immune Recognition of Viral Proteins by Surface Toll-like Receptors.表面抓挠的代价：表面 Toll 样受体对病毒蛋白的免疫识别。
Viruses. 2022 Dec 24;15(1):52. doi: 10.3390/v15010052.

本文引用的文献

1
A novel role for neutrophils as critical activators of NK cells.中性粒细胞作为自然杀伤细胞关键激活剂的新作用。
J Immunol. 2008 Nov 15;181(10):7121-30. doi: 10.4049/jimmunol.181.10.7121.
2
The secreted form of respiratory syncytial virus G glycoprotein helps the virus evade antibody-mediated restriction of replication by acting as an antigen decoy and through effects on Fc receptor-bearing leukocytes.呼吸道合胞病毒G糖蛋白的分泌形式通过充当抗原诱饵以及对携带Fc受体的白细胞产生影响，帮助病毒逃避抗体介导的复制限制。
J Virol. 2008 Dec;82(24):12191-204. doi: 10.1128/JVI.01604-08. Epub 2008 Oct 8.
3
H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice.H5N1和1918年大流行性流感病毒感染导致小鼠肺部巨噬细胞和中性粒细胞早期过度浸润。
PLoS Pathog. 2008 Aug 1;4(8):e1000115. doi: 10.1371/journal.ppat.1000115.
4
Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development.肺泡巨噬细胞是对病毒性肺部感染早期反应的主要决定因素，但不影响随后的疾病发展。
J Virol. 2008 May;82(9):4441-8. doi: 10.1128/JVI.02541-07. Epub 2008 Feb 20.
5
Effects of depletion of neutrophils or macrophages on the inflammatory response induced by metalloelastase (MMP-12) in mice airways.中性粒细胞或巨噬细胞耗竭对小鼠气道中金属弹性蛋白酶（MMP - 12）诱导的炎症反应的影响。
Eur J Pharmacol. 2008 Jan 28;579(1-3):374-81. doi: 10.1016/j.ejphar.2007.10.048. Epub 2007 Oct 25.
6
The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines.在接种减毒活呼吸道合胞病毒疫苗后发生野生型呼吸道合胞病毒感染时无疾病加重情况。
Vaccine. 2007 Oct 16;25(42):7372-8. doi: 10.1016/j.vaccine.2007.08.014. Epub 2007 Aug 28.
7
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.肺泡巨噬细胞是肺部感染RNA病毒时主要的α干扰素产生细胞。
Immunity. 2007 Aug;27(2):240-52. doi: 10.1016/j.immuni.2007.07.013.
8
Infiltrating neutrophils induce allospecific CTL in response to immunization with apoptotic cells via MCP-1 production.浸润的中性粒细胞通过产生单核细胞趋化蛋白-1（MCP-1），对凋亡细胞免疫作出反应，诱导同种特异性细胞毒性T淋巴细胞（CTL）。
J Leukoc Biol. 2007 Feb;81(2):412-20. doi: 10.1189/jlb.0606399. Epub 2006 Nov 9.
9
Granulocyte-macrophage colony-stimulating factor expressed by recombinant respiratory syncytial virus attenuates viral replication and increases the level of pulmonary antigen-presenting cells.重组呼吸道合胞病毒表达的粒细胞巨噬细胞集落刺激因子可减弱病毒复制并提高肺抗原呈递细胞水平。
J Virol. 2001 Dec;75(24):12128-40. doi: 10.1128/JVI.75.24.12128-12140.2001.
10
Contribution of the respiratory syncytial virus G glycoprotein and its secreted and membrane-bound forms to virus replication in vitro and in vivo.呼吸道合胞病毒G糖蛋白及其分泌型和膜结合型对病毒体内外复制的作用
Virology. 2001 Oct 25;289(2):283-96. doi: 10.1006/viro.2001.1138.

人呼吸道合胞病毒分泌的 G 蛋白拮抗涉及巨噬细胞和补体的抗体介导的复制限制。

The secreted G protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement.

机构信息

RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

J Virol. 2012 Oct;86(19):10880-4. doi: 10.1128/JVI.01162-12. Epub 2012 Jul 25.

DOI:10.1128/JVI.01162-12
PMID:22837211
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3457292/
Abstract

The respiratory syncytial virus (RSV) G and F glycoproteins are the neutralization antigens, and G also is expressed in a soluble form (sG). Previously, sG was demonstrated to reduce the efficiency of RSV antibody-mediated neutralization by serving as an antigen decoy and to inhibit the antibody-mediated antiviral effects of Fc receptor-bearing leukocytes. The present study demonstrated that effective antibody-mediated restriction in vivo, and the evasion of this restriction by sG, involves pulmonary macrophages and complement, but not neutrophils.

摘要

呼吸道合胞病毒 (RSV) 的 G 和 F 糖蛋白是中和抗原，G 蛋白也以可溶性形式 (sG) 表达。先前已经证实，sG 通过充当抗原诱饵来降低 RSV 抗体介导的中和效率，并抑制 Fc 受体表达的白细胞介导的抗病毒作用。本研究表明，体内有效的抗体介导的限制以及 sG 逃避这种限制涉及肺巨噬细胞和补体，但不涉及中性粒细胞。