Afarid Mehrdad, Hosseini Hamid, Abtahi Bagher
Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.
Middle East Afr J Ophthalmol. 2012 Jul-Sep;19(3):277-81. doi: 10.4103/0974-9233.97922.
The purpose of this study is to report the screening data for retinopathy of prematurity (ROP) at a screening center in Southern Iran.
A chart review was performed of all screened neonates who were referred to Poostchi screening center affiliated to Shiraz University of Medical Sciences from February 2006 to January 2010. Statistical analysis of data was performed with the Chi-square and independent t-test where appropriate. A P < 0.05 was considered statistically significant.
Of 787 infants referred, 293 (37.2%) had some form of ROP and 77 cases (9.8%) had plus disease, only 6 (2%) patients progressed to advanced ROP stages 4 and 5. The mean gestational age (GA) of patients with ROP (ROP group) was statistically significantly lower at 29.46 ± 2.31 weeks compared to patients without ROP (non-ROP group) (31.56 ± 2.03 weeks) (P < 0.05). The mean GA of patients with plus disease was statistically significantly lower at 28.92 ± 2.18 weeks compared to patients without plus disease (30.98 ± 2.30 weeks) (P < 0.05). The mean birth weight in the ROP group was statistically significantly lower at 1248.46 ± 301.75 g compared to the non-ROP group (1485.79 ± 268.66 g) (P < 0.05). The mean birth weight of patients with plus disease was statistically significantly lower at 1207.92 ± 334.79 g compared to patients without plus disease (417.99 ± 293.19 g) (P < 0.05). There was no difference in the occurrence of ROP or plus disease between single or multiple births, normal vaginal delivery, and caesarian section and between clomiphene users and nonusers (P > 0.05, all cases).
Greater cooperation between ophthalmologists, neonatologists, gynecologists, and health policy makers is necessary to optimize ROP screening programs. Data from this study can be used by health policy makers for implementation of health programs. These programs must include screening guidelines and effective coordination among the screening centers, antenatal, obstetric, and neonatal care services.
本研究旨在报告伊朗南部一家筛查中心的早产儿视网膜病变（ROP）筛查数据。
对2006年2月至2010年1月转诊至设拉子医科大学附属Poostchi筛查中心的所有接受筛查的新生儿进行病历回顾。在适当情况下，采用卡方检验和独立t检验对数据进行统计分析。P<0.05被认为具有统计学意义。
在787名转诊婴儿中，293名（37.2%）患有某种形式的ROP，77例（9.8%）患有附加病变，只有6名（2%）患者进展到ROP 4期和5期晚期。ROP患者（ROP组）的平均胎龄（GA）为29.46±2.31周，与无ROP患者（非ROP组）（31.56±2.03周）相比，在统计学上显著更低（P<0.05）。与无附加病变的患者（30.98±2.30周）相比，有附加病变患者的平均GA在统计学上显著更低，为28.92±2.18周（P<0.05）。ROP组的平均出生体重为1248.46±301.75克，与非ROP组（1485.79±268.66克）相比，在统计学上显著更低（P<0.05）。与无附加病变的患者相比，有附加病变患者的平均出生体重在统计学上显著更低，为1207.92±334.79克（417.99±293.19克）（P<0.05）。单胎或多胎、正常阴道分娩和剖宫产以及使用克罗米芬者与未使用者之间ROP或附加病变的发生率无差异（P>0.05，所有病例）。
眼科医生、新生儿科医生、妇科医生和卫生政策制定者之间需要加强合作，以优化ROP筛查项目。本研究的数据可供卫生政策制定者用于实施卫生项目。这些项目必须包括筛查指南以及筛查中心、产前、产科和新生儿护理服务之间的有效协调。
