Bourée Patrice, de Carsalade George-Yves
Faculté de médecine Paris-Sud, et institut Alfred-Fournier, 75014 Paris.
Rev Prat. 2012 Jun;62(6):751-5.
Leprosy, known since antiquity, is a world infectious disease due to Mycobacterium leprae. The transmission is probably via nasal droplets. The clinical range, from tuberculoid to lepromatous leprosy is a result of variation in the cell-mediated immune response, with a chronic inflammation in skin and peripheral nerves. Diagnosis of leprosy is clinical with anesthetic skin lesion and skin smears detect acid fast bacilli. Besides the classification of patients due to the Ridley scale which is clinically useful, WHO proposed is a simple field classification based on the number of skin patches (paucibacillary or multibacillary). Despite an effective multidrug therapy, leprosy has not been eliminated and remains an important health problem.
麻风病自古便为人所知,是一种由麻风分枝杆菌引起的全球性传染病。其传播可能通过飞沫传播。从结核样型到瘤型麻风病的临床范围是细胞介导免疫反应变化的结果,伴有皮肤和周围神经的慢性炎症。麻风病的诊断依靠临床症状(有无感觉缺失性皮肤损害)以及皮肤涂片检测抗酸杆菌。除了临床上有用的里德利分级法对患者进行分类外,世界卫生组织还提出了一种基于皮肤损害数量的简单现场分类法(少菌型或多菌型)。尽管有有效的联合化疗,但麻风病尚未被消灭,仍然是一个重要的健康问题。