Rebrova T Iu, Shipulin V M, Afanas'ev S A, Vorob'eva E V, Kiĭko O G
Kardiologiia. 2012;52(7):73-6.
We have studied the role of oxidant stress in development of rhythm disturbances in early postoperative period after coronary artery bypass grafting and possibilities of their prevention with preparations of ascorbinic acid. It was shown that the use of β-adrenoblockers allows to prevent arrhythmia on first day after operation only in 80% of cases. Patients with developed disturbances of cardiac rhythm were characterized by high parameters of lipid peroxidation (LPO) and substantial changes of activity of antioxidant enzyme catalase. Administration of ascorbinic acid at the stage of preparation of patients to surgery and in first 24 hours after operation allowed to effectively prevent development of oxidative stress and disturbances of cardiac rhythm. A conclusion was made that inclusion of ascorbinic acid in drug therapy of patients with ischemic heart disease could be recommended for prevention of arrhythmia in postoperative period.
我们研究了氧化应激在冠状动脉搭桥术后早期节律紊乱发生中的作用，以及使用抗坏血酸制剂预防这些紊乱的可能性。结果表明，使用β-肾上腺素能阻滞剂仅在80%的病例中可预防术后第一天的心律失常。发生心律失常紊乱的患者具有脂质过氧化（LPO）高参数和抗氧化酶过氧化氢酶活性的显著变化。在患者手术准备阶段和术后头24小时给予抗坏血酸可有效预防氧化应激的发生和心律失常紊乱。得出的结论是，建议在缺血性心脏病患者的药物治疗中加入抗坏血酸，以预防术后心律失常。
