无过渡金属超碱促进的酮与芳基乙炔的立体选择性α-乙烯基化反应：合成β,γ-不饱和酮的一般策略。
Transition-metal-free superbase-promoted stereoselective α-vinylation of ketones with arylacetylenes: a general strategy for synthesis of β,γ-unsaturated ketones.
机构信息
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch, Russian Academy of Sciences, 1 Favorsky Str., 664033 Irkutsk, Russia.
出版信息
J Org Chem. 2012 Aug 17;77(16):6880-6. doi: 10.1021/jo301005p. Epub 2012 Aug 9.
PMID:22839748
Abstract
A wide variety of β,γ-unsaturated ketones of E configuration have been obtained in good to excellent yields via KO(t)Bu/DMSO promoted α-vinylation of aliphatic, cycloaliphatic, and alkyl aromatic (heteroaromatic) ketones with diverse arylacetylenes.
摘要
通过 KO(t)Bu/DMSO 促进的脂肪族、脂环族和芳基（杂芳基）酮与各种芳基乙炔的α-乙烯基化反应，得到了多种 E 构型的β,γ-不饱和酮，产率良好至优秀。
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