基于羧甲基壳聚糖/有机累托石的复合纳米纤维垫及其细胞相容性。
Carboxymethyl chitin/organic rectorite composites based nanofibrous mats and their cell compatibility.
机构信息
College of Food Science and Technology and the MOE Key Laboratory of Environment Correlative Dietology, Huazhong Agricultural University, No. 1 Shizishan Road Wuhan 430070, China.
出版信息
Carbohydr Polym. 2012 Oct 1;90(2):1069-74. doi: 10.1016/j.carbpol.2012.06.045. Epub 2012 Jun 23.
In this study, carboxymethyl chitin (CMC) - organic rectorite (OREC)/poly (vinyl alcohol) (PVA) composite nanofibrous mats were successfully prepared via electrospinning. SAXRD pattern showed that the interlayer distance of OREC was increased from 3.68 to 4.08nm, which verified that polymer chains were intercalated into the interlayer of OREC. Field emission scanning electron microscopy, Fourier transform infrared spectra and energy-dispersive X-ray spectroscopy were used to characterize the morphology and microcosmic structure of nanofibrous mats. Thermal properties of mats were determined by differential scanning calorimetry. To evaluate the cell compatibility of mats, mouse lung fibroblast (L929) was chosen for cell attachment and spreading assay. The results shows that nanofibrous mats contained OREC have better thermal properties. Besides, the addition of OREC has little effect on the cell compatibility of nanofibrous mats.
在这项研究中，通过静电纺丝成功制备了羧甲基壳聚糖（CMC）-有机累托石（OREC）/聚乙烯醇（PVA）复合纳米纤维垫。SAXRD 图谱表明，OREC 的层间距从 3.68nm 增加到 4.08nm，这证明了聚合物链已插入 OREC 的层间。用场发射扫描电子显微镜、傅里叶变换红外光谱和能谱分析对纳米纤维垫的形貌和微观结构进行了表征。通过差示扫描量热法测定了垫子的热性能。为了评估垫子的细胞相容性，选择小鼠肺成纤维细胞（L929）进行细胞黏附和铺展试验。结果表明，含有 OREC 的纳米纤维垫具有更好的热性能。此外，OREC 的添加对纳米纤维垫的细胞相容性几乎没有影响。
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