Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Med Hypotheses. 2012 Oct;79(4):478-80. doi: 10.1016/j.mehy.2012.06.028. Epub 2012 Jul 26.
Following initial episode of sepsis, survivors suffer an increased risk of mortality that persists long-term and remains a significant health care problem. Opportunistic infections and neoplasms are more frequent partially accounting for shorter life expectancy. This suggests that during sepsis the immune system becomes aberrant and is unable to restore its optimal function after the initial insult. Dendritic cells (DC) or their precursors are frequently affected during the initial episode of sepsis as well as after the resolution of symptom. Considering these cells' pivotal role in regulating innate and acquired immune, they are promising candidates for therapeutic manipulation. Sepsis induces several changes in the populations of DCs via epigenetic, and/or other, mechanisms. Here, we propose that transplantation of 'naïve dendritic cells' (DCs which are never exposed to sepsis) can reverse several aspects of the long-term post-sepsis immunosuppression. Furthermore, we present advantages of the presented therapeutic approach.
在初次发生败血症后，幸存者的死亡率增加，这种情况长期持续存在，仍是一个重大的医疗保健问题。机会性感染和肿瘤更为常见，这在一定程度上导致了预期寿命缩短。这表明，在败血症期间，免疫系统会发生异常，并且在最初的损伤后无法恢复其最佳功能。树突状细胞（DC）或其前体在败血症的初始发作期间以及症状缓解后经常受到影响。鉴于这些细胞在调节先天和获得性免疫方面的关键作用，它们是治疗干预的有前途的候选者。败血症通过表观遗传和/或其他机制诱导 DC 群体发生多种变化。在这里，我们提出移植“幼稚树突状细胞”（从未接触过败血症的 DC）可以逆转败血症后长期免疫抑制的几个方面。此外，我们介绍了所提出的治疗方法的优势。
