Department of Anesthesiology and Critical Care, Department of Neurology, Leonard Davis Institute of Healthcare Economics, University of Pennsylvania, Philadelphia, PA 19194, USA.
Int J Mol Sci. 2021 Feb 27;22(5):2403. doi: 10.3390/ijms22052403.
(1) Background. Repetitive animal studies that have disappointed upon translation into clinical therapies have led to an increased appreciation of humanized mice as a remedy to the shortcomings of rodent-based models. However, their limitations have to be understood in depth. (2) Methods. This is a narrative, comprehensive review of humanized mice and sepsis literature to understand the model's benefits and shortcomings. (3) Results: Studies involving humanized models of sepsis include bacterial, viral, and protozoan etiology. Humanized mice provided several unique insights into the etiology and natural history of sepsis and are particularly useful in studying Ebola, and certain viral and protozoan infections. However, studies are relatively sparse and based on several different models of sepsis and humanized animals. (4) Conclusions. The utilization of humanized mice as a model for sepsis presents complex limitations that, once surpassed, hold some potential for the advancement of sepsis etiology and treatment.
(1) 背景。重复性的动物研究在转化为临床治疗时令人失望，这导致人们越来越重视将人源化小鼠作为解决基于啮齿动物模型的缺点的方法。然而，必须深入了解其局限性。(2) 方法。这是对人源化小鼠和脓毒症文献的叙述性、全面的综述，以了解该模型的优点和缺点。(3) 结果：涉及脓毒症人源化模型的研究包括细菌、病毒和原生动物病因。人源化小鼠为脓毒症的病因和自然史提供了一些独特的见解，在研究埃博拉病毒以及某些病毒和原生动物感染方面特别有用。然而，研究相对较少，并且基于几种不同的脓毒症模型和人源化动物。(4) 结论。将人源化小鼠用作脓毒症模型存在复杂的局限性，一旦克服这些局限性，就有可能推进脓毒症病因和治疗的发展。
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