Department of Paediatrics, School of Medicine, University of North Sumatera, Medan, Indonesia.
Asian Pac J Trop Med. 2012 Aug;5(8):605-9. doi: 10.1016/S1995-7645(12)60125-4.
To investigate the efficacy and effectiveness of albendazole and mebendazole in the treatment of Ascaris lumbricoides (A. lumbricoides) in the North-Western Indonesia.
229 primary school children who were positive for A. lumbricoides in their stool were recruited in the study. 123 children received single-dose of 400 mg albendazole and 106 children received single-dose 500 mg of mebendazole. After 1 week, their stools were examined for the cure rate (CR) and egg reduction rate (ERR). Egg culture was also performed and observation was made on week-1, -3, -4.
have shown a non-significant difference in CR 96.7%vs. 100% and ERR of 99.3%vs. 100.0% for albendazole and mebendazole groups respectively (P>0.05). In-vitro egg culture has shown trends of decrease in the percentage of the unfertilized eggs and in ≥ 2 cell eggs in both treatment groups (P<0.05). The embryonated eggs from the albendazole groups has shown an increase from 7.3% on week-1 to 13.8% on week-4, whilst the mebendazole group has shown a constant increase during the whole 4 weeks of culture from 7.5% to 28.3% (P<0.01).
No evidence of drug resistance is noted so far from the area of North-Western part of Indonesia. In addition, although both drugs showed incomplete ovicidal effects, single-dose albendazole is better than mebendazole in sterilizing A. lumbricoides eggs.
探讨阿苯达唑和甲苯达唑治疗印度尼西亚西北部鞭虫（A. lumbricoides）的疗效和效果。
研究招募了 229 名粪便中鞭虫阳性的小学生。123 名儿童服用单剂量 400 mg 阿苯达唑，106 名儿童服用单剂量 500 mg 甲苯达唑。1 周后，检查粪便以确定治愈率（CR）和卵减少率（ERR）。还进行了卵培养，并在第 1、3、4 周观察。
阿苯达唑组的 CR 为 96.7%，甲苯达唑组的 CR 为 100%，两组无显著差异；阿苯达唑组的 ERR 为 99.3%，甲苯达唑组的 ERR 为 100.0%，两组无显著差异（P>0.05）。体外卵培养显示，两组的未受精卵和≥2 细胞卵的百分比均呈下降趋势（P<0.05）。阿苯达唑组的受精卵从第 1 周的 7.3%增加到第 4 周的 13.8%，而甲苯达唑组在整个 4 周的培养过程中从 7.5%持续增加到 28.3%（P<0.01）。
迄今为止，印度尼西亚西北部地区尚未发现耐药证据。此外，尽管两种药物的杀卵效果均不完全，但单剂量阿苯达唑在杀灭鞭虫卵方面优于甲苯达唑。
