美金刚对路易体痴呆前驱期患者的影响。
The effects of memantine on a patient having preclinical dementia with Lewy bodies.
机构信息
Department of Psychiatry, Osaka General Medical Center, Osaka 558-8558, Japan.
出版信息
Gen Hosp Psychiatry. 2013 May-Jun;35(3):327.e1-327.e3. doi: 10.1016/j.genhosppsych.2012.06.017. Epub 2012 Jul 25.
OBJECTIVE
Memantine has been reported to have positive effects on visual hallucinations and cognition in patients with dementia with Lewy bodies (DLB). We hypothesized that memantine would have similar effects on a patient having Charles Bonnet syndrome, preclinical DLB.
METHOD
We evaluated the effect of memantine on visual hallucination, cognitive abilities and so on from baseline to 4 months after the start of medication.
RESULTS
Treatment of the patient with memantine resulted in the disappearance of visual hallucinations but could not stop the progression to dementia.
CONCLUSIONS
Our results suggested that, for a patient having preclinical DLB, memantine had some degree of positive effects, but the mechanism remains to be revealed.
目的
有报道称，美金刚对路易体痴呆（DLB）患者的视幻觉和认知功能有积极影响。我们假设美金刚对处于临床前期的 DLB 的 Charles Bonnet 综合征患者也有类似作用。
方法
我们评估了从基线到用药开始后 4 个月期间美金刚对视幻觉、认知能力等的影响。
结果
美金刚治疗该患者导致视幻觉消失，但无法阻止向痴呆发展。
结论
我们的结果表明，对于处于临床前期的 DLB 患者，美金刚有一定程度的积极作用，但机制仍有待揭示。
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