Department of Otolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, and School of Medicine, Chang Gung University, College of Medicine, Taoyuan, Taiwan, ROC.
Oral Oncol. 2013 Jan;49(1):86-92. doi: 10.1016/j.oraloncology.2012.07.001. Epub 2012 Jul 25.
To investigate the intraepithelial microvascular morphology of oral squamous cell carcinoma (OSCC) by using narrow-band imaging (NBI) and analyze whether the intraepithelial papillary capillary loop (IPCL) patterns correlate with infiltration depth and disease severity in OSCC.
The clinicopathologic data, morphology of vascular architecture as observed by NBI, and histopathology of patients with OSCC were retrospectively reviewed and analyzed.
A total of 80 patients, including 73 males and 7 females with an average age of 54.18±12.23 years, were enrolled. Three patterns of intraepithelial microvasculature were revealed by NBI and differences in these three patterns were significant with regard to pathologic T-classification (p<0.0001), N-classification (p=0.00022), TNM stage (p<0.0001), lymphovascular invasion (p<0.0001), perineural invasion (p=0.000299), depth of tumor infiltration (p<0.0001), and tumor differentiation (p<0.0001). A cut-off point of tumor infiltration of 10.012 mm was best predicted for the destructive pattern of IPCL (sensitivity=100%, specificity=90.0%).
Three different patterns of IPCL, showing step-wise increased severity according to pathologic parameters, were observed by NBI in cases of OSCC. The pattern indicating IPCL destruction with angiogenesis was associated with more advanced disease stage.
利用窄带成像（NBI）研究口腔鳞状细胞癌（OSCC）的上皮内微血管形态，并分析上皮内乳头状毛细血管袢（IPCL）模式是否与 OSCC 的浸润深度和疾病严重程度相关。
回顾性分析了 80 例 OSCC 患者的临床病理资料、NBI 观察到的血管结构形态以及组织病理学资料。
共纳入 80 例患者，其中男性 73 例，女性 7 例，平均年龄 54.18±12.23 岁。NBI 显示上皮内微血管有 3 种形态，这 3 种形态在病理 T 分期（p<0.0001）、N 分期（p=0.00022）、TNM 分期（p<0.0001）、淋巴血管侵犯（p<0.0001）、神经周围侵犯（p=0.000299）、肿瘤浸润深度（p<0.0001）和肿瘤分化程度（p<0.0001）方面存在显著差异。IPCL 破坏模式的肿瘤浸润临界值为 10.012mm 时预测效果最佳（灵敏度为 100%，特异性为 90.0%）。
在 OSCC 中，NBI 观察到 3 种不同的 IPCL 模式，根据病理参数显示出逐步增加的严重程度。提示存在血管生成的 IPCL 破坏模式与更晚期的疾病阶段相关。
