Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung; No. 222, Mai Chin Road, Keelung, 204, Taiwan.
School of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan.
BMC Cancer. 2015 May 15;15:406. doi: 10.1186/s12885-015-1422-7.
To analyze the clinical application of endoscope with narrow-band imaging (NBI) system in detecting high-grade dysplasia, carcinoma in situ, and carcinoma in oral erythroplakia.
The demographic, histopathological data, and NBI vasculature architectures of patients receiving surgical intervention for oral erythroplakia were retrospectively reviewed and analyzed statistically.
A total of 72 patients, including 66 males and 6 females, with mean age of 54.6 ± 11.2 years, were enrolled. The odds ratio of detecting high-grade dysplasia, carcinoma in situ, and carcinoma by twisted elongated morphology and destructive pattern of intraepithelial microvasculature was 15.46 (confidence interval 95%: 3.81-72.84), and the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 80.95%, 78.43%, 60.71%, 90.91%, and 79.17%, respectively, which were significantly better than other two established NBI criteria (p < 0.001).
Twisted, elongated, and destructive patterns of intraepithelial papillary capillary loop of NBI images are indicators for high-grade dysplasia, carcinoma in situ, and invasive carcinoma in oral erythroplakia.
分析窄带成像（NBI）系统在内窥镜下检测口腔红斑高异型增生、原位癌和浸润癌的临床应用。
回顾性分析接受口腔红斑手术干预患者的人口统计学、组织病理学数据和 NBI 血管结构，并进行统计学分析。
共纳入 72 例患者，男 66 例，女 6 例，平均年龄 54.6±11.2 岁。扭曲拉长形态和上皮内微血管破坏模式检测高级别异型增生、原位癌和癌的优势比为 15.46（95%置信区间：3.81-72.84），灵敏度、特异度、阳性预测值、阴性预测值和准确度分别为 80.95%、78.43%、60.71%、90.91%和 79.17%，均明显优于其他两种已建立的 NBI 标准（p<0.001）。
NBI 图像上皮内乳头状毛细血管袢的扭曲、拉长和破坏模式是口腔红斑高异型增生、原位癌和浸润癌的指标。
