Liverani C A, Lattuada D, Mangano S, Pignatari C, Puglia D, Monti E, Bolis G
Department of Mother and Infant Sciences, University of Milan, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
J Pediatr Adolesc Gynecol. 2012 Aug;25(4):e81-3. doi: 10.1016/j.jpag.2011.10.002.
Donovanosis is a chronic bacterial illness, progressive and indolent, which normally attacks the skin and mucous membranes in the genital and perigenital regions.
An 18-year-old pregnant female presented with large, hypertrophic lesions in the ano-genital region. HIV serology was negative. Pap smear revealed a CIN 1 associated with HPV infection. Biopsy yielded macrophages laden with Gram-negative Donovan bodies.
A diagnosis of vulvar and perianal donovanosis was reached; the patient decided to terminate the pregnancy and was treated with azithromycin, which led to clinical resolution.
软性下疳是一种慢性细菌性疾病，病程进展缓慢，通常侵袭生殖器及生殖器周围区域的皮肤和黏膜。
一名18岁的怀孕女性，其肛门生殖器区域出现巨大的肥厚性病变。HIV血清学检测为阴性。巴氏涂片显示为与HPV感染相关的CIN 1。活检发现巨噬细胞内充满革兰氏阴性的杜诺凡小体。
诊断为外阴及肛周软性下疳；患者决定终止妊娠，并接受阿奇霉素治疗，临床症状得以缓解。
