Pharmaceutical Laboratory, Applied Sciences Group, Health Sciences Authority, 11 Outram Road, Singapore 169078, Singapore.
J Pharm Biomed Anal. 2012 Nov;70:265-72. doi: 10.1016/j.jpba.2012.07.008. Epub 2012 Jul 16.
Two new phosphodiesterase-5 inhibitors (PDE-5) which consist of one sildenafil analogue and one thiosildenafil analogue have been found in heath supplements. The structural properties of these analogues have been elucidated by NMR, high resolution MS, MS(2), UV and IR spectroscopy. The sildenafil analogue is very similar to aildenafil and the thiosildenafil analogue is similar to thioaildenafil, except the ethoxy group bonded to phenyl ring is replaced by a propoxy group. Hence, the sildenafil analogue is named as propoxyphenyl aildenafil or propoxyphenyl methisosildenafil and the thiosildenafil analogue as propoxyphenyl thioaildenafil or propoxyphenyl thiomethisosildenafil.
两种新的磷酸二酯酶-5 抑制剂（PDE-5）已在保健品中被发现，它们由一个西地那非类似物和一个硫代西地那非类似物组成。这些类似物的结构性质已通过 NMR、高分辨率 MS、MS(2)、UV 和 IR 光谱学阐明。西地那非类似物与伐地那非非常相似，而硫代西地那非类似物与硫代艾地那非相似，只是连接苯环的乙氧基被丙氧基取代。因此，西地那非类似物被命名为丙氧苯基昔多芬或丙氧苯基甲硫昔多芬，而硫代西地那非类似物则被命名为丙氧苯基硫代艾地那非或丙氧苯基硫代甲硫昔多芬。
