Zou Peng, Hou Peiling, Oh Sharon Sze-Yin, Chong Y M, Bloodworth Bosco Chen, Low Min-Yong, Koh Hwee-Ling
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
J Pharm Biomed Anal. 2008 Jun 9;47(2):279-84. doi: 10.1016/j.jpba.2008.01.016. Epub 2008 Jan 18.
Two unknown compounds are detected and isolated from health supplements for the enhancement of sexual function. The structures of the unknown compounds are elucidated using high-resolution MS, ESI-MS/MS, NMR, UV and IR. One compound is identified as an analogue of sildenafil in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety, and an ethyl group instead of a methyl group is attached to the piperazinyl nitrogen. Hence, this compound is named thiohomosildenafil. Another compound is also a sildenafil analogue in which the oxygen atom is substituted with a sulfur atom in the pyrazolopyrimidine moiety. This compound is named thiosildenafil. Both the two compounds are first detected in health supplements. The UV, IR and completely assigned NMR data of thiohomosildenafil and thiosildenafil are first reported.
从用于增强性功能的健康补充剂中检测并分离出两种未知化合物。使用高分辨率质谱、电喷雾串联质谱、核磁共振、紫外光谱和红外光谱对这些未知化合物的结构进行了阐明。一种化合物被鉴定为西地那非类似物，其中吡唑并嘧啶部分的氧原子被硫原子取代，并且连接到哌嗪氮上的是乙基而非甲基。因此，该化合物被命名为硫代高同型西地那非。另一种化合物也是西地那非类似物，其中吡唑并嘧啶部分的氧原子被硫原子取代。该化合物被命名为硫代西地那非。这两种化合物均首次在健康补充剂中被检测到。首次报道了硫代高同型西地那非和硫代西地那非的紫外光谱、红外光谱以及完全归属的核磁共振数据。
