Tuncer M, Tekin S, Yücetin L, Şengül A, Demirbas A
Medicalpark Antalya, Organ Transplant Center, Lara, Antalya, Turkey.
Transplant Proc. 2012 Jul-Aug;44(6):1626-7. doi: 10.1016/j.transproceed.2012.05.045.
Paired-exchange kidney transplantation (PETx) gains an importance because it is difficult to find suitable organs. The aim of this study was to compare biochemical and clinical parameters of PETx with those of living-related kidney transplantation (LRTx).
The 57 PETx included 18 female and 39 male recipients among 1081 LRTx in 360 females and 721 males (N = 1138) whose operations were performed between November 21, 2008, and March 1, 2011. These two groups were compared for graft and patient survival, rejections, serum creatinine levels, glomerular filtration rates (GFRs), and other biochemical parameters.
The PETx patients were older than the LRTx patients (45.4 ± 13.2 years versus 40.9 ± 13.5 years; P = .014). HLA mismatch was higher in the PETx group (4.7 ± 0.7 versus 3.56 ± 1.6; P = .000). First- and second-year serum creatinine and GFR values were similar between the two groups. Acute rejection episodes (PETx: 13/57; LRTx: 226/1081, P = .925), patient loss (0/57 versus 34/1081; P = .174) and graft loss (1/57 versus 55/1081; P = .257) were similar between the two groups.
Our study showed similar biochemical and clinical findings of PETx versus LRTx over 2 years posttransplantation.
由于难以找到合适的器官，配对交换肾移植（PETx）变得愈发重要。本研究旨在比较PETx与亲属活体肾移植（LRTx）的生化及临床参数。
57例PETx受者中，女性18例，男性39例，来自于2008年11月21日至2011年3月1日期间进行手术的1138例LRTx受者（女性360例，男性721例）。比较两组的移植物和患者生存率、排斥反应情况、血清肌酐水平、肾小球滤过率（GFR）以及其他生化参数。
PETx患者比LRTx患者年龄更大（45.4±13.2岁对40.9±13.5岁；P = 0.014）。PETx组的人类白细胞抗原（HLA）错配率更高（4.7±0.7对3.56±1.6；P = 0.000）。两组的第一年和第二年血清肌酐及GFR值相似。两组间急性排斥反应发生率（PETx：13/57；LRTx：226/1081，P = 0.925）、患者死亡情况（0/57对34/1081；P = 0.174）和移植物丢失情况（1/57对55/1081；P = 0.257）相似。
我们的研究表明，PETx与LRTx在移植后2年的生化及临床结果相似。
