Clinicopathologic and radiologic correlation of ossifying fibroma and juvenile ossifying fibroma--an institutional study of 22 cases.

To analyze the clinical, radiographic, and histopathologic features of ossifying fibroma (OF) and juvenile OF (JOF), an archival study of 17 cases of OF and 5 cases of JOF reported over a period of 4.5 years was undertaken to analyze the aforementioned features. Age incidence of OF varied from 8 to 53 years, and JOF was seen in a comparatively younger age of 8 to 28 years. Both tumors were almost equally distributed between men and women. Thirteen cases of OF were found to occur in posterior mandible, whereas JOF was predominant in the anterior maxilla. Radiographically, OF varied from completely radiolucent (n = 7), mixed (n = 5), to completely radiopaque (n = 5), whereas JOF was predominantly radiolucent. Microscopically, stroma in OF varied from fibrous to highly cellular with overlap between various types of calcification. Juvenile OF showed highly cellular stroma and 2 distinct patterns of mineralization-psammomatoid and trabecular with osteoid seams. The origin of OF and JOF seems to be distinct from each other with OF arising from periodontal ligament and JOF arising from precursor myxoid tissue of paranasal sinuses.