CPMT Group, Department of Applied Engineering Sciences, University College Ghent, Voskenslaan 362, 9000 Ghent, Belgium.
J Mech Behav Biomed Mater. 2012 Sep;13:78-84. doi: 10.1016/j.jmbbm.2012.04.009. Epub 2012 Apr 24.
Freshly excised porcine aortic heart valve cusps were subjected to a uni-axial flexural indentation test, from which the rupture characteristics and a functional stiffness parameter were determined. It was found that the flexural mechanical properties of aortic valve cusps (i) are unaffected by their coronary position and (ii) are sensitive to the effect of mechanical preconditioning. The resulting values of the cusp's flexural mechanical properties are intended as a set of reference properties which scaffolds, meant for the tissue engineering of heart valves, must approximate in order to be considered as a functional replacement.
新鲜取出的猪主动脉心脏瓣膜瓣叶接受了单轴弯曲压痕测试，由此确定了破裂特征和功能刚度参数。研究发现，主动脉瓣瓣叶的弯曲力学性能（i）不受其冠状动脉位置的影响，（ii）对机械预处理的效果敏感。瓣叶弯曲力学性能的结果值旨在作为一组参考性能，用于心脏瓣膜组织工程的支架必须近似这些参考性能，才能被认为是功能替代物。
