Department of Pathology, University of Debrecen, Nagyerdei krt. 98., 4032, Debrecen, Hungary.
Pathol Oncol Res. 2012 Oct;18(4):761-9. doi: 10.1007/s12253-012-9534-8. Epub 2012 Jul 29.
One of the basic requirements during the process of cell division is to maintain genetic integrity and ensure normal ploidy. The family of Aurora kinases, composed of Aurora A, B and C, takes a major role in the control of centrosome cycle, mitotic entry, chromosome condensation and coordination of chromosomal movements. Deregulation of kinase expression was described in a series of different malignancies which was also associated with aneuploidy. Recently, Aurora kinases gained significant interest as potential therapeutic targets in oncology. While there is increasing evidence about the activities of Aurora A kinase during cancer progression, data are controversial regarding the role of Aurora B. In this review the biology of Aurora kinases and its potential relation to cancer progression is discussed with special focus on functional changes and determination of Aurora B kinase.
细胞分裂过程中的基本要求之一是保持遗传完整性并确保正常的倍性。Aurora 激酶家族由 Aurora A、B 和 C 组成，在控制中心体周期、有丝分裂进入、染色体浓缩和染色体运动协调方面起着重要作用。激酶表达的失调在一系列不同的恶性肿瘤中被描述，并且与非整倍体有关。最近，Aurora 激酶作为肿瘤学中的潜在治疗靶点引起了广泛关注。虽然越来越多的证据表明 Aurora A 激酶在癌症进展中的活性，但关于 Aurora B 的作用的数据存在争议。在这篇综述中，讨论了 Aurora 激酶的生物学及其与癌症进展的潜在关系，特别关注功能变化和 Aurora B 激酶的测定。
