Department of Obstetrics and Gynecology, 4 Rue de la Chine, 75020 Paris, France.
Anticancer Res. 2012 Aug;32(8):3571-9.
For ductal intraepithelial neoplasia, grade 1B, studies that predict breast cancer risk after an 11-gauge vacuum-assisted breast biopsy have yielded contradictory results. In order to identify a predictive model of breast cancer risk, we assessed the underestimation rate according to radiological and clinical findings.
Our study involved 212 patients. We compared the area under the receiver operating characteristic curves and the clinical utility of a logistic regression and partitioning model.
Overall upgrade to malignancy occurred in 42 (19.8%) out of the 212 cases. The area under the curve for the logistic regression and partitioning model were 0.65 (95% confidence interval=0.61-0.70) and 0.58 (95% confidence interval=0.54-0.62), respectively. The lowest predicted underestimation rate obtained with the logistic regression model was 9.5%.
From this large series, we were unable to define any accurate safety model for breast cancer. Surgery should be thus recommended.
对于导管上皮内瘤变 1B 级，预测 11 号空芯针活检后乳腺癌风险的研究结果相互矛盾。为了确定乳腺癌风险的预测模型，我们根据影像学和临床发现评估了低估率。
我们纳入了 212 例患者。我们比较了接受者操作特征曲线下面积以及逻辑回归和分区模型的临床实用性。
212 例患者中，整体恶性升级的有 42 例（19.8%）。逻辑回归和分区模型的曲线下面积分别为 0.65（95%置信区间=0.61-0.70）和 0.58（95%置信区间=0.54-0.62）。逻辑回归模型预测的最低低估率为 9.5%。
本大系列研究未能明确任何针对乳腺癌的准确安全模型。因此，建议行手术治疗。
