Truelle J L, Chanelet J, Bastard J, Six P, Emile J
Nouv Presse Med. 1977 Oct 8;6(33):2987-90.
Sixty cases of Parkinson's disease were treated with piribedil alone (dose : 274 mg/day, duration : 20,4 months). The overall clinical improvement, confirmed by recordings of tremor and EMG, was 34%, tremor being improved of 59%. Before treatment, an intravenous test does of piribedil with recording made it possible to predict the effectiveness of oral treatment. Side-effects (vasomotor, digestive, psychiatric) were moderate. Orthostatic hypotension, dyskinesia and fluctuations were exceptional. The basic indication for piribedil lies in forms of recent onset in which tremor predominates, patients in whom L-dopa is contraindicated and a certain number in whom the latter has failed (tremor, fluctuating action).
60例帕金森病患者仅接受了吡贝地尔治疗（剂量：274毫克/天，疗程：20.4个月）。通过震颤记录和肌电图证实，总体临床改善率为34%，震颤改善率为59%。治疗前，通过静脉注射吡贝地尔并进行记录的试验能够预测口服治疗的效果。副作用（血管舒缩、消化、精神方面）较为轻微。直立性低血压、运动障碍和症状波动情况罕见。吡贝地尔的基本适应证在于近期发病且以震颤为主的类型、左旋多巴禁忌的患者以及一定数量使用左旋多巴治疗失败的患者（震颤、动作波动）。
