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吡贝地尔治疗帕金森病(作者译)

[Piribedil in the treatment of Parkinson disease (author's transl)].

作者信息

Nardini M, Sciannandrone R, Fieschi C, De Simone G

出版信息

Riv Patol Nerv Ment. 1975 Mar-Apr;96(2):103-10.

PMID:778998
Abstract

Seventeen patients with either Parkinson's disease or post-encephalitic parkinsonism were treated with Piribedil, an apomorphine-like drug, in single blind conditions for a period ranging from five weeks to twenty-four months. The analysis of the results shows that Piribedil modifies the extrapiramidal symptomatology being specially effective against the tremor either when used alone or in association with L-Dopa. The side effects noticed during treatment with Piribedil are similar to those of Apomorphine, and are dose-dependent.

摘要

17名帕金森病或脑炎后帕金森综合征患者在单盲条件下接受了阿扑吗啡样药物吡贝地尔治疗,疗程为5周至24个月。结果分析表明,吡贝地尔可改善锥体外系症状,单独使用或与左旋多巴联合使用时对震颤特别有效。吡贝地尔治疗期间出现的副作用与阿扑吗啡相似,且与剂量有关。

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