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遗传变异在 REC8、RNF212 和 PRDM9 影响牛的雄性重组。

Genetic variants in REC8, RNF212, and PRDM9 influence male recombination in cattle.

机构信息

Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.

出版信息

PLoS Genet. 2012;8(7):e1002854. doi: 10.1371/journal.pgen.1002854. Epub 2012 Jul 26.

DOI:10.1371/journal.pgen.1002854
PMID:22844258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3406008/
Abstract

We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.

摘要

我们利用在 >10000 个公牛精子细胞中识别出的 >250000 个交叉事件，对雄性奶牛的减数分裂重组进行了广泛的特征描述。我们绘制了影响全基因组重组率、全基因组热点使用和基因座特异性重组率的数量性状基因座（QTL）图谱。我们对三个 QTL 进行了精细定位，并提供了强有力的证据表明 REC8 和 RNF212 中的遗传变异影响全基因组重组率，而 PRDM9 中的遗传变异影响全基因组热点使用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/6016f636cb25/pgen.1002854.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/a9a8ba67beaf/pgen.1002854.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/4e1551d9181d/pgen.1002854.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/21d3aabc5010/pgen.1002854.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/cb07cad6613b/pgen.1002854.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/6016f636cb25/pgen.1002854.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/a9a8ba67beaf/pgen.1002854.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/4e1551d9181d/pgen.1002854.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/21d3aabc5010/pgen.1002854.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/cb07cad6613b/pgen.1002854.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2fb/3406008/6016f636cb25/pgen.1002854.g005.jpg

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