Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea.
Gut Liver. 2012 Jul;6(3):321-7. doi: 10.5009/gnl.2012.6.3.321. Epub 2012 May 22.
BACKGROUND/AIMS: The potential role of the cyclooxygenase (COX)-2 polymorphism has been reported in relation to the risk of gastrointestinal tract malignancies. Therefore, we investigated whether COX-2 polymorphisms are associated with the risk of gastric cancer (GC) in Korea, one of the areas with a high prevalence of this condition.
We evaluated the genotypic frequencies of COX-2-765 and -1195 in 100 peptic ulcer patients, 100 GC patients, and 100 healthy controls. The polymorphisms of the COX-2-765 and -1195 genes were analyzed by polymerase chain reaction and restriction fragment length polymorphisms.
The frequencies of the COX-2-1195 GG, GA, and AA genotype were 20%, 60%, and 20% in intestinal-type GC and 8%, 48%, and 44% in diffuse-type GC, respectively (p=0.021). There were no significant differences in the frequency of COX-2-765 genotypes between intestinal-type GC and diffuse-type GC (p=0.603). Age- and sex-adjusted logistic regression analysis showed that the COX-2-1195 AA genotype was the independent risk factor of diffuse-type GC compared with the COX-2-1195 GG genotype (p=0.041; odds ratio, 6.22; 95% confidence interval, 1.077 to 35.870).
The COX-2-1195 AA genotype may render subjects more susceptible to diffuse-type GC.
背景/目的：环氧化酶（COX）-2 多态性与胃肠道恶性肿瘤的风险有关，其潜在作用已有报道。因此，我们研究了 COX-2 多态性是否与韩国（胃癌高发地区之一）胃癌（GC）的风险相关。
我们评估了 100 例消化性溃疡患者、100 例 GC 患者和 100 例健康对照者 COX-2-765 和-1195 的基因型频率。COX-2-765 和-1195 基因的多态性通过聚合酶链反应和限制性片段长度多态性进行分析。
COX-2-1195 GG、GA 和 AA 基因型在肠型 GC 中的频率分别为 20%、60%和 20%，弥漫型 GC 中的频率分别为 8%、48%和 44%（p=0.021）。肠型 GC 和弥漫型 GC 之间 COX-2-765 基因型的频率无显著差异（p=0.603）。年龄和性别调整的逻辑回归分析表明，与 COX-2-1195 GG 基因型相比，COX-2-1195 AA 基因型是弥漫型 GC 的独立危险因素（p=0.041；优势比，6.22；95%置信区间，1.077 至 35.870）。
COX-2-1195 AA 基因型可能使患者更容易患弥漫型 GC。
