Pereira Carina, Sousa Hugo, Ferreira Paula, Fragoso Maria, Moreira-Dias Luís, Lopes Carlos, Medeiros Rui, Dinis-Ribeiro Mário
Serviço de Gastrenterologia, Instituto Português de Oncologia do Porto FG EPE, Rua Dr. António Bernardino Almeida, 4200-072 Porto, Portugal.
World J Gastroenterol. 2006 Sep 14;12(34):5473-8. doi: 10.3748/wjg.v12.i34.5473.
To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma.
A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method.
-765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).
-765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.
研究-765G>C环氧化酶-2（COX-2）基因多态性与不同胃病变（萎缩或肠化生以及胃腺癌）发生之间的关系。
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法对320名葡萄牙人进行了一项横断面研究，其中包括210名无肿瘤疾病证据者、73名胃腺癌患者以及37名有萎缩或肠化生患者。
与对照组（38%）或萎缩或肠化生患者组（27%）相比，胃腺癌患者中-765C等位基因的比例过高（51%）。在我们的人群中发现C等位基因非常常见（0.22），多因素逻辑回归分析显示，携带-765C等位基因的萎缩或肠化生患者进展为胃腺癌的风险增加近3倍（比值比=2.67，95%可信区间=1.03-6.93；P=0.04）。
-765C携带状态应被视为萎缩或肠化生患者发生胃腺癌的另一个易感性标志物。
