Department of Radiology, Dong-A Medical Center, Dong-A University College of Medicine, Busan, Korea.
Gut Liver. 2012 Jul;6(3):362-7. doi: 10.5009/gnl.2012.6.3.362. Epub 2012 May 2.
BACKGROUND/AIMS: The purpose of this study was to assess the value of acoustic radiation force impulse (ARFI) for predicting the extent of radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) by correlating the elasticity of HCC and peritumoral parenchyma (as measured by ARFI) with the extent of ablation determined by computed tomography (CT).
From September 2009 to June 2011, 158 patients underwent RFA ablation for HCC (single, ≤3 cm). We evaluated the data of a total of 38 prospectively enrolled patients who underwent both ARFI imaging and contrast-enhanced CT after one session of 12 minutes of RFA without a change in needle position. The ARFI imaging indices, including the mean shear wave velocity (SWV) of HCC, mean SWV of the peritumoral parenchyma and tumor size, were evaluated to determine the statistical correlation with RFA extent after one session of 12 minutes of RFA.
A stiffer liver parenchyma in patients with cirrhosis results in a smaller ablation zone.
SWV of ARFI in liver parenchyma was well correlated with RFA extent. After evaluating the correlation between ARFI and RFA extent, we suggest that the SWV in liver parenchyma might be a non-invasive supplementary tool for predicting the extent of RFA.
背景/目的：本研究旨在通过将 HCC 的弹性（通过 ARFI 测量）与 CT 确定的消融范围相关联，评估声辐射力脉冲（ARFI）在预测 HCC 射频消融（RFA）范围中的价值。
2009 年 9 月至 2011 年 6 月，158 例 HCC 患者接受 RFA 消融（单个，≤3cm）。我们评估了总共 38 例前瞻性入组患者的数据，这些患者在不改变针位的情况下接受了 12 分钟的 RFA 治疗，之后进行了 ARFI 成像和增强 CT。评估了 ARFI 成像指标，包括 HCC 的平均剪切波速度（SWV）、肿瘤周围肝实质的平均 SWV 和肿瘤大小，以确定与 12 分钟 RFA 后一次治疗的消融范围的统计学相关性。
肝硬化患者的肝实质较硬导致消融区域较小。
ARFI 的 SWV 与 RFA 范围密切相关。在评估 ARFI 与 RFA 范围之间的相关性后，我们建议肝实质中的 SWV 可能是预测 RFA 范围的一种非侵入性辅助工具。
