Oishi Katsutaka
Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST).
Nihon Rinsho. 2012 Jul;70(7):1109-14.
The suprachiasmatic nucleus (SCN) is considered the master circadian pacemaker that controls most of the physical circadian rhythms of mammals including behavior. Studies of clock genes have implied that oscillatory mechanisms function in peripheral organs and isolated cells, and that they are entrained to the SCN. The circadian clock is an intracellular, transcriptional-translational mechanism that shares the same molecular components in the SCN and in peripheral cells. Hundreds of tissue-specific circadian genes that regulate an impressive diversity of biological processes have been identified using DNA microarray technology. This review summarized the recent information of clock and clock-controlled genes in mammals.
视交叉上核（SCN）被认为是控制包括行为在内的大多数哺乳动物生理昼夜节律的主昼夜起搏器。对时钟基因的研究表明，振荡机制在周围器官和分离的细胞中起作用，并且它们受SCN的调节。昼夜节律钟是一种细胞内的转录 - 翻译机制，在SCN和外周细胞中具有相同的分子成分。使用DNA微阵列技术已经鉴定出数百种调节令人印象深刻的生物过程多样性的组织特异性昼夜节律基因。本综述总结了哺乳动物中时钟和时钟控制基因的最新信息。
