García del Palacio J I, Sánchez Hernández I, Palomero Gil A, Montero Rey D
Hospital de Enfermedades del Tórax, Los Montalvos, Salamanca.
Rev Clin Esp. 1990 Jul-Aug;187(3):115-20.
Nine hundred and sixty six patients diagnosed of pulmonary and/or pleural tuberculosis and admitted to a specialized hospital from 1948 to 1986, have been retrospectively analyzed, investigating their treatment and evolution. Sixty two percent of patients did not fulfil pharmaceutical treatment as far as number and dose of drugs, evolving through the decades (50, 60, 70, and 80s) with a 100%, 82%, 37% and 3% respectively. A 13% of patients did not receive any chemotherapy, 16% underwent surgery, and 53% received a second treatment. Real or hidden monotherapy was given to 38% of patients. Isoniazide has been the most uniformly used drug. Streptomycin has been the most frequently underdosed used drug. Sputum culture turned negative in 42% and 51% of patients during the first 3 and 6 months respectively, with a 42% of positives persisting after one year and a 30% when discharged. A statistically significant difference is observed when comparing all the variables between admitted patients up to 1969 and from 69 to 86 in favor of the second period.
对1948年至1986年间诊断为肺结核和/或胸膜结核并入住专科医院的966例患者进行了回顾性分析，研究他们的治疗情况和病情演变。就药物数量和剂量而言，62%的患者未完成药物治疗，在几十年间（50年代、60年代、70年代和80年代）分别有100%、82%、37%和3%的患者出现这种情况。13%的患者未接受任何化疗，16%的患者接受了手术，53%的患者接受了二次治疗。38%的患者接受了实际或隐性的单一疗法。异烟肼是使用最普遍的药物。链霉素是使用时剂量最常不足的药物。分别有42%和51%的患者在最初3个月和6个月时痰培养转阴，一年后仍有42%的患者痰培养阳性，出院时为30%。比较1969年以前入院的患者和1969年至1986年入院的患者的所有变量时，观察到有统计学意义的差异，结果有利于第二个时期。
