Pascau P, Serrano Ríos M, Senén D, Alonso M L, Saban J
Cátedra de Medicina Interna II, Hospital Clínico de San Carlos, Madrid.
Rev Clin Esp. 1990 Jul-Aug;187(3):125-7.
We present the study of a patient suffering insulin resistance with Werner's syndrome which had abnormal glucose tolerance determined by euglycemic fixing ("Clamp") using an artificial pancreas (Biostator GCIIS, Miles Martin) and the binding of insulin to its receptor in erythrocytes. The results obtained show a dose-response curve of insulin serum levels to dextrose infusion rate, shifted significantly to the right and bottom which indicates a diminished insulin sensitivity; similarly a moderate decrease in receptor is obtained with no decrease in their affinity and absence of abnormalities in contraregulatory hormones. These results are compatible with a postreceptor alteration.
我们报告了一项针对患有胰岛素抵抗且伴有沃纳综合征患者的研究，该患者通过使用人工胰腺（Biostator GCIIS，迈尔斯·马丁公司）进行正常血糖钳夹试验（“钳夹法”）测定其葡萄糖耐量异常，并检测了胰岛素与红细胞中胰岛素受体的结合情况。所获得的结果显示，胰岛素血清水平对葡萄糖输注速率的剂量反应曲线明显向右下方移动，这表明胰岛素敏感性降低；同样，受体有适度减少，但亲和力未降低，且反调节激素无异常。这些结果与受体后改变相符。
