Blohmé G, Smith U
Diabete Metab. 1979 Jun;5(2):119-24.
A case of Werner's syndrome was investigated with regard to the immune system and peripheral insulin sensitivity. Routine immunological screening revealed no abnormality in either humoral or cell-mediated immune response. Intravenous glucose tolerance test showed a reduced glucose tolerance coupled with very high insulin levels. There was no evidence for increased levels of antagonistic hormones e.g., corticosteroids, growth hormone or thyroid hormones. Serum insulin binding capacity was normal. Adipose tissue metabolism revealed a reduced sensitivity to the effects of insulin both on glucose metabolism and on the antilipolytic effect. This was purely due to a shift in the dose-response curve to the right since maximal effects were the same as those found in control subjects. This reduced insulin sensitivity seems to be due to a reduction in the number of cellular insulin receptors.
对一例沃纳综合征患者的免疫系统和外周胰岛素敏感性进行了研究。常规免疫筛查显示，体液免疫或细胞介导的免疫反应均无异常。静脉葡萄糖耐量试验显示葡萄糖耐量降低，同时胰岛素水平极高。没有证据表明拮抗激素（如皮质类固醇、生长激素或甲状腺激素）水平升高。血清胰岛素结合能力正常。脂肪组织代谢显示，胰岛素对葡萄糖代谢和抗脂解作用的敏感性降低。这纯粹是由于剂量反应曲线向右移动，因为最大效应与对照组相同。这种胰岛素敏感性降低似乎是由于细胞胰岛素受体数量减少所致。
